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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Simple and Efficient Synthesis of 1,4- and 1,5-Dioxepan-2-one
- Source: Letters in Organic Chemistry, Volume 6, Issue 6, Sep 2009, p. 478 - 480
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- 01 Sep 2009
Abstract
A novel synthesis of 1,4- and 1,5-dioxepan-2-one lactones was achieved through the regioselective oxidation of 3-(2-hydroxyethoxy)propan-1-ol. Under basic conditions, when 3-(2-hydroxyethoxy)propan-1-ol was oxidized using oxoammonium salts, a quantitative oxidative esterification was observed, resulting in a regioselective lactone ring closure. This oxidation was tailored to afford 1,4-dioxepan-2-one in very good yield.
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