A Convenient Synthesis of 1-Alkyl-7-chloro-6-fluoro-3-nitro-4-quinolones

Raed A. Al-Qawasmeh; Jalal A. Zahra; Monther A. Khanfar; Yusuf M. AL-Hiari; Mustafa M. El-Abadelah; Wolfgang Voelter

doi:10.2174/157017809789124812

ISSN: 1570-1786
E-ISSN: 1875-6255

A Convenient Synthesis of 1-Alkyl-7-chloro-6-fluoro-3-nitro-4-quinolones
By Raed A. Al-Qawasmeh, Jalal A. Zahra, Monther A. Khanfar, Yusuf M. AL-Hiari, Mustafa M. El-Abadelah and Wolfgang Voelter
Source: Letters in Organic Chemistry, Volume 6, Issue 6, Sep 2009, p. 511 - 514
DOI: https://doi.org/10.2174/157017809789124812
- Available online: 01 Sep 2009

Abstract

A convenient one-pot synthesis of 1-alkyl-7-chloro-6-flouro-3-nitro-1,4-dihydro-4-quinolones is described via nitro-decarboxylation of the respective 4-oxo-1,4-dihydroquinoline-3-carboxylic acid precursors. Reduction of the former 3-nitroquinolones delivered the corresponding 3-aminoquinolones, envisaged as valuable synthons in drug research.

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2009-09-01

2025-12-11

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Article Type: Research Article

Keyword(s): 1-alkyl-3-nitro-4-quinolones; 1-alkyl-4-oxoquioline-3-carboxylic acids; 1-cycloalkyl-3-nitro-4-quinolones; Fluoroquinolones; fuming nitric acid; nitro-decarboxylation

A Convenient Synthesis of 1-Alkyl-7-chloro-6-fluoro-3-nitro-4-quinolones

Abstract

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