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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Azaphilone α-Bromoacetates (AzαBs): Fluorescent Linchpin Reagents for the Inter- and Intramolecular Cross-Linkage of Primary Amines to Thiols
- Source: Letters in Organic Chemistry, Volume 6, Issue 5, Jul 2009, p. 367 - 371
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- 01 Jul 2009
Abstract
α-Bromoacetate esters of the azaphilone isochromene-6,8-dione core exhibit a pH-dependent orthogonal reactivity allowing for the one-pot cross-linkage of primary amines to thiols in an inter- or intramolecular fashion to afford fluorescent products. This represents a new potential strategy for bioconjugate chemistry.
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