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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis and Antitumor Evaluation of Thiophene Analogs of Kigelinone
- Source: Letters in Organic Chemistry, Volume 6, Issue 4, Jun 2009, p. 278 - 281
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- 01 Jun 2009
Abstract
The synthesis of kigelinone thiophene analogs and related naphtho[2,3-b]thiophene-4,9-quinones from 2- substituted 4,7-dimethoxybenzo[b]thiophenes via an oxidative deprotection, Diels-Alder, and oxidative aromatization reaction sequence is reported. The 2-substituted naphtho[2,3-b]thiophene-4,9-quinones display significant antitumor activity in the range IC50 1.1-47 μM on a panel of four distinct human cancer cell lines.
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