Synthesis of Novel Laurenditerpenol Analogues and their Evaluation as HIF-1 Activation Inhibitors

Employing a flexible synthetic strategy towards laurenditerpenol, two analogues featuring the 7- oxabicyclo[2.2.1]heptane ring system present in the natural product have been prepared and their ability to inhibit HIF-1 activation has been evaluated. Their weak activity indicates the importance of the cyclohexenol part of the prototype.