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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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First Synthesis of Lissoclimide-Type Alkaloids
- Source: Letters in Organic Chemistry, Volume 6, Issue 4, Jun 2009, p. 289 - 292
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- 01 Jun 2009
Abstract
The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the aldehyde γ-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.
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