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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Solvent-Free Microwave-Assisted Synthesis of New 2-Aryl-Tetrahydroquinolines Using Three-Component Povarov Reaction
- Source: Letters in Organic Chemistry, Volume 6, Issue 3, Apr 2009, p. 208 - 212
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- 01 Apr 2009
Abstract
A new series of 2-aryl-1,2,3,4-tetrahydroquinolines has been synthesized in good yields through a BiCl3- catalyzed three-component Povarov reaction (imino Diels-Alder cycloaddition) between anilines, benzaldehydes and Nvinylpyrrolidin- 2-one in MeCN. The same series has been prepared without solvent using microwave radiation, which resulted in better yields, a considerable decrease in reaction times and simplified workup.
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