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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Method for the Syntheses of Enopyranosides
- Source: Letters in Organic Chemistry, Volume 6, Issue 3, Apr 2009, p. 191 - 196
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- 01 Apr 2009
Abstract
Sodium hydride (NaH) in hexamethylphosphoric triamide (HMPA) has been introduced as an economical and efficient reagent towards the creation of 1,2- or 5,6-enopyranosides from the corresponding halogenated or tosylated pyranosides. NaH/HMPA has several advantages compared to NaH/DMF: elimination products are produced in high yields even from sterically-hindered halides as well as tosylates.
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