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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Chiral Recognition of 2-Hydroxypropyl-alpha-cyclodextrin Towards DLTryptophan
- Source: Letters in Organic Chemistry, Volume 6, Issue 3, Apr 2009, p. 258 - 263
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- 01 Apr 2009
Abstract
In this report, the recognition points of tryptophan by 2-hydroxypropyl-alpha-cyclodextrin (HPαCD) are presented. This cyclodextrin exhibited greater thermodynamic chiral selectivity towards DL-tryptophan than the hydroxypropylated beta form. FTIR spectroscopy was used to tentatively evidence this chiral discrimination in solid state HPαCDTrp complexes. An inclusion complex was only detected for the HPαCD-DTrp sample, while HPαCD-LTrp immediately decomposed after crystallization, which left a mechanical mixture of tryptophan and cyclodextrin.
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