New Solid-Phase Approach to Synthesize a Hyacinthacine Core Using the L-Proline as a Building Block

A new solid-phase synthesis of pyrrolizidine nucleus related to hyacinthacine core using L-proline as the starting material is reported. The final step is a new approach with a cyclization-cleave strategy, which releases the product from the resin in good yields under Baylis-Hillman conditions.