The Stereoselective Total Synthesis of (1S,1'R,5'R,7'R)-1-hydroxy-exo- Brevicomin by a Chiron Approach

(1S,1'R,5'R,7'R)-1-Hydroxy-exo-brevicomin has been synthesized in a highly efficient manner using Dglucono- δ-lactone as a chiral precursor. The synthesis involves the Grignard cross coupling, Wacker oxidation and intramolecular acetalization as the key steps.