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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis and Anti-HSV-1 In Vitro Activity of New Phosphoramidates with 4-oxoquinoline and Phtalimidic Nuclei
- Source: Letters in Organic Chemistry, Volume 5, Issue 8, Dec 2008, p. 644 - 650
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- 01 Dec 2008
Abstract
Aminoalkyl phosphoramidates were obtained by either direct phosphorylation of symmetric diamines or a three steps method analogue to Gabriel's synthesis and coupled to a 4-oxoquinoline acyclonucleoside, in order to synthesize 4- oxoquinolone phosphoramidates. Two unpublished compounds demonstrated low cytotoxity in comparison to Acyclovir and good HSV-1 cytophatic effects on Acyclovir resistant strains.
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