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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Enantioselective Michael Addition of Dimethyl Malonate to (E)-β- Nitrostyrenes Catalyzed by Cinchona Alkaloids Under Solvent-Free Condition
- Source: Letters in Organic Chemistry, Volume 5, Issue 8, Dec 2008, p. 602 - 606
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- 01 Dec 2008
Abstract
Under solvent-free condition the addition of dimethyl malonate (1) to (E)-β-nitrostyrenes 2a-j proceeds smoothly in the presence of 2.5 mol% of 6'-hydroxy cinchonine (QD-OH) and equimolar amounts of reagents at 30 °C. The corresponding products 3a-j are obtained with satisfactory enantiomeric excesses (68-88%) and high yields (70- 92%).
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