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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Novel Three-Component Reaction of Dibenzylamine and an Aromatic Aldehyde with an Alkyl Isocyanide in the Presence of Silica Gel: An Efficient Route for the One-Pot Synthesis of Sterically Congested 2-(Dibenzylamino)-2-Aryl Acetamide Derivatives
- Source: Letters in Organic Chemistry, Volume 5, Issue 7, Oct 2008, p. 540 - 543
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- 01 Oct 2008
Abstract
Addition of an isocyanide to an iminium ion intermediate that forms from the reaction between an aromatic aldehyde and dibenzylamine, leads to formation of sterically congested 2-(dibenzylamino)-2-aryl acetamide derivatives in the presence of silica gel powder.
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