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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Melatonin Receptor Antagonist Luzindole: A Facile New Synthesis
- Source: Letters in Organic Chemistry, Volume 5, Issue 6, Sep 2008, p. 507 - 509
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- 01 Sep 2008
Abstract
A new, convenient and high yield route to luzindole, the most commonly used melatonin receptor antagonist, is described. The new method involves the Sonogashira coupling reaction between 2-iodoaniline and 3-phenyl-1-propyne followed by cyclisation of the adduct formed, C-3 indole nitroolefination with 1-(dimethylamino)-2-nitroethylene/TFA, reduction to the respective tryptamine and finally acetylation.
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