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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues
- Source: Letters in Organic Chemistry, Volume 5, Issue 5, Jul 2008, p. 399 - 402
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- 01 Jul 2008
Abstract
Gly8-GLP-1 (7∼36) amide and Exendin- 4, analogues of Glucagon-like peptide-1 (GLP-1), were synthesized rapidly and efficiently on rink amide MBHA resin under microwave irradiation, using Fmoc/tBu orthogonal protection strategy. The results showed that the synthesis of the medium- to large-length peptides was greatly improved in the reaction time and the purity of crude product with the use of microwave irradiation.
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