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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Enantioselective Synthesis of 2, 6-Disubstituted Dihydropyrone Derivatives Catalyzed by TiCl4/BINOL/RONa System
- Source: Letters in Organic Chemistry, Volume 5, Issue 5, Jul 2008, p. 391 - 395
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- 01 Jul 2008
Abstract
A facile method for the preparation of chiral pyrone derivatives through hetero-Diels-Alder reaction is described. Sodium alcoholates were used as efficient additives in the enantioselective reactions catalyzed by MCl4 (M = Ti4+, Sn4+) / (R)-BINOL systems. The optically resulted active 2, 6-disubsituted dihydropyrones could be obtained with up to 94% ees and 88% yields.
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