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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Concise Formal Synthesis of (±)-Shikonin Via a Highly α-Regioselective Prenylation of 1, 4, 5, 8-Tetramethoxynaphthalene-2-Carbaldehyde
- Source: Letters in Organic Chemistry, Volume 5, Issue 3, Apr 2008, p. 234 - 236
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- 01 Apr 2008
Abstract
A concise formal synthesis of (±)-shikonin via a highly α-regioselective prenylation is achieved. The novelty of the procedure lies in the introduction of side chain of shikonin in one step via prenylation of 1, 4, 5, 8- tetramethoxynaphthalene-2-carbaldehyde under mild conditions without producing any γ-isomer.
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