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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis of 13C and 15N Isotope Labeled Triazine Inhibitors for the Mechanistic Study of Dihydropteridine Reductase
- Source: Letters in Organic Chemistry, Volume 12, Issue 9, Nov 2015, p. 659 - 662
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- 01 Nov 2015
Abstract
13C and 15N isotope labeled precursors and 6-amino-2,3-dimethylpyrimido[4,5-e][1,2,4] triazine-8-one were synthesized for the mechanistic study of dihydropteridine reductase (DHPR). Structures of precursors and the inhibitors were confirmed by UV/Vis, 13C NMR, and ESI-MS measurements.
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