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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines
- Source: Letters in Organic Chemistry, Volume 5, Issue 2, Mar 2008, p. 103 - 109
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- 01 Mar 2008
Abstract
The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential antiproliferative effects.
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