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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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One-Pot Synthesis of Norfloxacin Ethyl Ester from 3-Chloro-4- Fluoroaniline in Ionic Liquid
- Source: Letters in Organic Chemistry, Volume 5, Issue 1, Jan 2008, p. 1 - 2
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- 01 Jan 2008
Abstract
Norfloxacin ethyl ester was prepared from 3-chloro-4-fluoroaniline in ionic liquid in a one-pot procedure by condensation with EMME [ethoxymethylenemalonic diethyl ester], cyclization, ethylation and condensation with anhydrous piperazine. After its hydrolysis, norfloxacin was obtained with an overall yield of 72.7%.
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