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2000
Volume 4, Issue 8
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

A series of bifunctional compounds carrying cluster thiogalactosides L1-L6 as the cell targeting ligands were synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly(ethylene glycol) chain with different length. This design provided an effective entry for the synthesis of the bifunctional compound with hepatocytes targeting ability.

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/content/journals/loc/10.2174/157017807782795510
2007-12-01
2025-10-02
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