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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Asymmetric Aldol Additions with a Titanium Enolate of N-Thioglycolyl Oxazolidinethione
- Source: Letters in Organic Chemistry, Volume 4, Issue 7, Oct 2007, p. 456 - 461
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- 01 Oct 2007
Abstract
A titanium enolate of N-thioglycolyl oxazolidinethione has been prepared and used for the synthesis of "Evans" syn aldol adducts, in good yield and high selectivity. Removal of the chiral auxiliary was accomplished by reduction to the corresponding 1,3-diols or by preparation of Weinreb amides.
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