Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3'-Azido-3'-Deoxythymidine

Some steroidal phosphorothioate, phosphoroselenoate, and phosphate derivatives conjugated with 3'-Azido-3'-deoxythymidine (AZT) have been synthesized in good yields and their structures were confirmed on the basis of spectral methods. The result has shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.