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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Nanoclay-Catalyzed Tandem Conjugate Addition-Annulation Protocol for Imidazo-1,3-Thiazines
- Source: Letters in Organic Chemistry, Volume 4, Issue 3, Apr 2007, p. 218 - 221
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- 01 Apr 2007
Abstract
A nanoclay-catalyzed atom and energy-efficient low hazardous tandem conjugate additioncyclodehydration of cyclic thioureas (ethylenethiourea and 2-mercaptoimidazole/-benzimidazole) with dielectrophiles (chalcones) readily annulates a 1,3-thiazine ring on imidazoles to yield 7H-imidazo[2,1-b]-1,3- thiazines under solvent-free microwave irradiation in a one-pot procedure.
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