Multicomponent Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones with a Cu/Silica Xerogel Composite Catalyst

The efficient multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by a heterogeneous Cu/silica xerogel composite is presented herein. This composite was synthesized by the sol-gel methodology employing CuCl2 as the metal source. The catalyst can be easily recovered and reused in subsequent reactions.