Multicomponent Solvent-Free Cyclocondensation/Glycosylation Strategy for Thiazolo-s-triazine N-Nucleosides

Lal Dhar Singh Yadav; Vijai Kumar Rai; Seema Yadav

doi:10.2174/157017807780037469

ISSN: 1570-1786
E-ISSN: 1875-6255

Multicomponent Solvent-Free Cyclocondensation/Glycosylation Strategy for Thiazolo-s-triazine N-Nucleosides
Authors: Lal Dhar Singh Yadav¹, Vijai Kumar Rai² and Seema Yadav³
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¹ Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211 002, India. ² Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211 002, India. ³ Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211 002, India.
Source: Letters in Organic Chemistry, Volume 4, Issue 1, Jan 2007, p. 47 - 50
DOI: https://doi.org/10.2174/157017807780037469
- Available online: 01 Jan 2007

Abstract

A green protocol involving novel three-component one-pot cyclocondensation reactions of 2- amino-4-aryl-thiazoles, aromatic aldehydes and ammonium thiocyanate under solvent-free microwave irradiation (MWI) conditions expeditiously yields thiazolo-s-triazine nucleobases, which afford the corresponding pyrano N-nucleosides on I2 promoted glycosylation with 1,2,3,4-tetra-O-acetyl- β-D-ribo- /xylopyranose under MWI followed by deacetylation.

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2007-01-01

2025-12-19

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Article Type: Research Article

Keyword(s): glycosylation; microwaves; Multicomponent reactions; pyrano N-nucleosides; solvent-free; thiazolo-s-triazines

Multicomponent Solvent-Free Cyclocondensation/Glycosylation Strategy for Thiazolo-s-triazine N-Nucleosides

Abstract

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