Nucleophilic Substitution Reactions in Ionic Liquid: Towards a Real Continuous-Flow Process for Synthesis of Alkyl Bromides and Cyanides

Zhiming Wang; Zhe Li; Weiliang Bao

doi:10.2174/157017807780037333

ISSN: 1570-1786
E-ISSN: 1875-6255

Nucleophilic Substitution Reactions in Ionic Liquid: Towards a Real Continuous-Flow Process for Synthesis of Alkyl Bromides and Cyanides
Authors: Zhiming Wang¹, Zhe Li² and Weiliang Bao³
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¹ Department of Chemistry, Zhejiang University, Xi Xi Campus, Hangzhou, Zhejiang 310028, P. R. China. ² Department of Chemistry, Zhejiang University, Xi Xi Campus, Hangzhou, Zhejiang 310028, P. R. China. ³ Department of Chemistry, Zhejiang University, Xi Xi Campus, Hangzhou, Zhejiang 310028, P. R. China.
Source: Letters in Organic Chemistry, Volume 4, Issue 1, Jan 2007, p. 72 - 74
DOI: https://doi.org/10.2174/157017807780037333
- Available online: 01 Jan 2007

Abstract

A real continuous-flow process for synthesis of alkyl bromides or cyanides was demonstrated by nucleophilic substitution reactions of tosylates with bromide and/or cyanide conducted in ionic liquid 1- ethyl-3-methylimidazolium tosylate. The process provides higher yields and shorter reaction time and is easily upgraded to large scale.

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2007-01-01

2025-11-04

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Article Type: Research Article

Keyword(s): alkyl bromide; alkyl cyanide; Continuous-flow process; distillation; ionic liquid; nucleophilic substitution reaction

Nucleophilic Substitution Reactions in Ionic Liquid: Towards a Real Continuous-Flow Process for Synthesis of Alkyl Bromides and Cyanides

Abstract

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