Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery

Xiaochun Wu; Yong Wu; Li Hai; Ying Bao

doi:10.2174/157017806779468004

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery
Authors: Xiaochun Wu¹, Yong Wu², Li Hai³ and Ying Bao⁴
View Affiliations Hide Affiliations

¹ Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China. ² Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China. ³ Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China. ⁴ Key Laboratory of Drug Targeting and Novel Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China.
Source: Letters in Organic Chemistry, Volume 3, Issue 12, Dec 2006, p. 911 - 914
DOI: https://doi.org/10.2174/157017806779468004
- Available online: 01 Dec 2006

Abstract

A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.

Article metrics loading...

/content/journals/loc/10.2174/157017806779468004

2006-12-01

2025-12-15

From This Site

/content/journals/loc/10.2174/157017806779468004

dcterms_title,dcterms_subject,pub_keyword

-contentType:Contributor -contentType:Concept -contentType:Institution

10

5

Full text loading...

/content/journals/loc/10.2174/157017806779468004

Article Type: Research Article

Keyword(s): Cholesterylated carboxylic acid; gene delivery; oligo(ethylene glycols); targeting ligand

Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery

Abstract

From This Site

Most Read This Month

Most Cited Most Cited RSS feed

Vilsmeier-Haack Cyclisation as a Facile Synthetic Route to Thieno [2,3- b] Quinolines (Part I)

Efficient Synthesis of 4-Arylmethylene-3-methylisoxazol-5(4H)-one Derivatives Catalyzed by Malic Acid

Novel Derivatives Based on Zerumbone Scaffold as Potential Anticancer Inhibitors

Wonderful Natural Drugs with Surprising Nutritional Values, Rheum Species, Gifts of the Nature

A Review on the Syntheses and Applications of the 5H-chromeno[2,3- b]pyridines

Fe Doped Ga2O3 Nanomaterial Catalysed Green and Efficient One Pot Three Component Synthesis of Tetrahydrobenzo[b]pyran

Sulfonated Ethylenediamine Functionalized Magnetic Nanoparticles as a Highly Efficient Heterogeneous Nanocatalyst for the Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

K2CO3/TBAB, a Composite of Inorganic and Organic Salts, a Novel and Powerful Media for Regioselective Michael Addition of Dihydropyrimidinones to Acrylic Esters Under and Without Solvent Conditions

In-silico Approach for Evaluation of Antimalarial Potential of Costunolide Synthase Enzyme and Sesquiterpene Lactones from Cichorium intybus

Indole Derivatives: Versatile Scaffolds in Drug Development and Cancer Therapeutics