Diastereoselective Addition of Organolithium to Ferrocene-Carboxaldehyde Imines Derived from (R)- and (S)-1-Phenylethylamine: The Effect of External Additives

Hui-Qing Zhang; Zhi-Ming Zhou; Min Fang

doi:10.2174/157017806779117085

ISSN: 1570-1786
E-ISSN: 1875-6255

Diastereoselective Addition of Organolithium to Ferrocene-Carboxaldehyde Imines Derived from (R)- and (S)-1-Phenylethylamine: The Effect of External Additives
Authors: Hui-Qing Zhang¹, Zhi-Ming Zhou² and Min Fang³
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¹ School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081, China. ² School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081, China. ³ School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081, China.
Source: Letters in Organic Chemistry, Volume 3, Issue 11, Nov 2006, p. 802 - 805
DOI: https://doi.org/10.2174/157017806779117085
- Available online: 01 Nov 2006

Abstract

An efficient and flexible asymmetric synthesis of chiral ferrocenylamines 3a-c via diastereoselective addition of organolithium compounds to chiral imines is described. High diastereoselectivity(93% de) was observed with ferrocenecarboxaldehyde imine 2b in the presence of the Lewis acids BF3oOEt2.

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2006-11-01

2025-09-18

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Article Type: Research Article

Keyword(s): asymmetric addition; chiral synthesis; Ferrocene; ferrocenecarboxaldehyde imine; optically active amines; organolithium compounds

Diastereoselective Addition of Organolithium to Ferrocene-Carboxaldehyde Imines Derived from (R)- and (S)-1-Phenylethylamine: The Effect of External Additives

Abstract

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