Synthesis of Pyrido[3,2-c]coumarin Derivatives by an Intramolecular Cyclization of 4-Methyl-2-(ortho-methoxyphenyl)nicotinic Acid Using Eaton's Reagent

Yoshinobu Tagawa; Kenji Yamagata; Kunihiro Sumoto

doi:10.2174/157017806779025951

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis of Pyrido[3,2-c]coumarin Derivatives by an Intramolecular Cyclization of 4-Methyl-2-(ortho-methoxyphenyl)nicotinic Acid Using Eaton's Reagent
Authors: Yoshinobu Tagawa¹, Kenji Yamagata² and Kunihiro Sumoto³
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¹ Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Jonan-ku, Fukuoka 814 -0180 Japan. ² Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Jonan-ku, Fukuoka 814 -0180 Japan. ³ Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8-19-1, Jonan-ku, Fukuoka 814 -0180 Japan.
Source: Letters in Organic Chemistry, Volume 3, Issue 10, Oct 2006, p. 759 - 763
DOI: https://doi.org/10.2174/157017806779025951
- Available online: 01 Oct 2006

Abstract

The reaction of 4-methyl-2-(methoxyphenyl)nicotinic acid with Eaton's reagent (P2O5 - CH3SO3H) affords pyrido[3,2-c]coumarin derivatives or 1-methyl-4-azafluoren-9-ones depending on the position of the methoxy group on the benzene ring.

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2006-10-01

2025-09-16

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Article Type: Research Article

Keyword(s): 1-methyl-4-azafluoren-9-one; Eaton's reagent; intramolecular cyclization; methoxy group; Pyrido[3,2-c]coumarin

Synthesis of Pyrido[3,2-c]coumarin Derivatives by an Intramolecular Cyclization of 4-Methyl-2-(ortho-methoxyphenyl)nicotinic Acid Using Eaton's Reagent

Abstract

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