A Facile Two-Step Chemo-Enzymatic Synthesis of GDP-Mannose

Gang-Liang Huang; Xiang Liu; Hou-Cheng Zhang; Peng-George Wang

doi:10.2174/157017806778700015

ISSN: 1570-1786
E-ISSN: 1875-6255

A Facile Two-Step Chemo-Enzymatic Synthesis of GDP-Mannose
Authors: Gang-Liang Huang¹, Xiang Liu², Hou-Cheng Zhang³ and Peng-George Wang⁴
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¹ State Key Laboratory of Microbial Technology (SKLMT), Shandong University, Jinan, Shandong 250100, China. ² State Key Laboratory of Microbial Technology (SKLMT), Shandong University, Jinan, Shandong 250100, China. ³ State Key Laboratory of Microbial Technology (SKLMT), Shandong University, Jinan, Shandong 250100, China. ⁴ State Key Laboratory of Microbial Technology (SKLMT), Shandong University, Jinan, Shandong 250100, China.
Source: Letters in Organic Chemistry, Volume 3, Issue 9, Sep 2006, p. 668 - 669
DOI: https://doi.org/10.2174/157017806778700015
- Available online: 01 Sep 2006

Abstract

Mannose is selectively converted into mannose-1-phosphate (Man-1-P, 1) without protection of the other hydroxyl groups by phosphorylation of the anomeric hydroxyl in dry tetrahydrofuran (THF) containing phosphoric acid. Compound 1 is activated with GTP and recombinant GDP-mannose pyrophosphorylase (GDPMan PP) to give GDP-Man 2.

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2006-09-01

2025-11-07

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Article Type: Research Article

Keyword(s): chemo-enzymatic synthesis; GDP-Man; Man-1-P; two-step

A Facile Two-Step Chemo-Enzymatic Synthesis of GDP-Mannose

Abstract

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