A Novel and Convenient Method for the Synthesis of Ubiquinone-10

Feng Wang; Xiangrui Jiang; Lihong Hu; Shengyi Dong; Xiumei Wu; Hua Bai; Yongmin Zhang; Joachim Stockigt; Yu Zhao

doi:10.2174/157017806778559464

ISSN: 1570-1786
E-ISSN: 1875-6255

A Novel and Convenient Method for the Synthesis of Ubiquinone-10
Authors: Feng Wang¹, Xiangrui Jiang², Lihong Hu³, Shengyi Dong⁴, Xiumei Wu⁵, Hua Bai⁶, Yongmin Zhang⁷, Joachim Stockigt⁸ and Yu Zhao⁹
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¹ Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China. ² Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China. ³ Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China. ⁴ Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China. ⁵ Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China. ⁶ Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China. ⁷ Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China. ⁸ Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China. ⁹ Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Gudun Road, Hangzhou 310058, P.R. China.
Source: Letters in Organic Chemistry, Volume 3, Issue 8, Aug 2006, p. 610 - 612
DOI: https://doi.org/10.2174/157017806778559464
- Available online: 01 Aug 2006

Abstract

A novel and convenient synthetic approach to ubiquinone-10 was reported via the SN2'-type nucleophilic displacement reaction between copper-catalyzed Grignard reagent and the secondary allylic acetate, which was suitable for the large-scale production of ubiquinone-10.

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2006-08-01

2025-10-03

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Article Type: Research Article

Keyword(s): copper-catalyzed; Grignard reagent; regioselectivity; secondary allylic acetate; SN2'-type reaction; stereoselectivity

A Novel and Convenient Method for the Synthesis of Ubiquinone-10

Abstract

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