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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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The Influence of Base on Regioselectivity of 5-Substituted Uracils Addition to Michael Acceptors
- Source: Letters in Organic Chemistry, Volume 3, Issue 7, Jul 2006, p. 534 - 538
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- 01 Jul 2006
Abstract
Michael type addition reaction of 5-substituted uracil derivatives to methyl acrylate and acrylonitrile has been studied. The regioselectivity of adducts has been observed due to the 5-substituent present in the uracil ring and the applied base. When triethylamine was used as a deprotonating agent, exclusively N-1 adducts were obtained. In the presence of DBU in DMF solution as the major products, N-3 adducts were isolated.
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