Synthesis of 2-Diphenylphosphinoyl-2'-Halo Biphenyls Via Suzuki-Miyaura Coupling as Possible Route to Non-Symmetric Biphenyl Phosphines

The preparation of 2-diphenylphosphinoyl-2'-halogenated biphenyls led to gaining interesting insight into the Suzuki-Miyaura coupling of ortho-halogenated penylboronic acids. Advantages and limitations on the use of halogenated biphenyls for the synthesis of diphosphine ligands are presented.