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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Oxepin- and Spiro-Annulation of 2-Pyridone in Conjunction with Claisen Rearrangement and Ruthenium Carbene Complex Mediated Enyne Metathesis (SUPPORTING DATA)
- Source: Letters in Organic Chemistry, Volume 3, Issue 7, Jul 2006, p. 526 - 529
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- 01 Jul 2006
Abstract
A direct synthesis of substituted oxepin and spiroheterocycles has been achieved from substrates derived from 4-hydroxy-1,6-dimethyl pyridine-2-ones (1) by combining Claisen rearrangement and ring closing enyne metathesis. The RCEM proceeded smoothly under nitrogen atmosphere at room temperature in the presence of well-defined ruthenium catalyst A (10 mol%).
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