Convergent Synthetic Studies Towards the Ribosyl-Diazepanone Core of the Liposidomycins

Yann Bourdreux; Bruno Drouillat; Christine Greck

doi:10.2174/157017806776611827

ISSN: 1570-1786
E-ISSN: 1875-6255

Convergent Synthetic Studies Towards the Ribosyl-Diazepanone Core of the Liposidomycins
Authors: Yann Bourdreux¹, Bruno Drouillat² and Christine Greck³
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¹ Institut Lavoisier de Versailles, UMR CNRS 8180, Universite de Versailles St-Quentin-en- Yvelines, 45, avenue des Etats Unis, 78035 Versailles Cédex, France. ² Institut Lavoisier de Versailles, UMR CNRS 8180, Universite de Versailles St-Quentin-en- Yvelines, 45, avenue des Etats Unis, 78035 Versailles Cédex, France. ³ Institut Lavoisier de Versailles, UMR CNRS 8180, Universite de Versailles St-Quentin-en- Yvelines, 45, avenue des Etats Unis, 78035 Versailles Cédex, France.
Source: Letters in Organic Chemistry, Volume 3, Issue 5, May 2006, p. 368 - 370
DOI: https://doi.org/10.2174/157017806776611827
- Available online: 01 May 2006

Abstract

New types of ribosyl-diazepanone derivatives of nucleoside antibiotic liposidomycins, 12a and 12b, have been synthesised. The ribosyl 7-membered heterocycles were formed by reductive amination of the α-ribosylamino acid 9 derived from D-ribose and the amino aldehydes 10a or 10b, followed by a peptidic coupling reaction.

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2006-05-01

2025-09-16

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Article Type: Research Article

Keyword(s): Antibiotic; diazepanone; lactamisation; liposidomycin; ribosylamino acid

Convergent Synthetic Studies Towards the Ribosyl-Diazepanone Core of the Liposidomycins

Abstract

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