Synthesis of 5-Substituted-1,3,4-Oxadiazole-2(3H)-Thiones Under Microwave Irradiation

Khalid M. Khan; Sohail A. Shahzad; Mubeen Rani; Muhammad Ali; Shahnaz Perveen; Awais Anwar; Wolfgang Voelter

doi:10.2174/157017806776114522

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis of 5-Substituted-1,3,4-Oxadiazole-2(3H)-Thiones Under Microwave Irradiation
Authors: Khalid M. Khan¹, Sohail A. Shahzad², Mubeen Rani³, Muhammad Ali⁴, Shahnaz Perveen⁵, Awais Anwar⁶ and Wolfgang Voelter⁷
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¹ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ² H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ³ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁴ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁵ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁶ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. ⁷ H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
Source: Letters in Organic Chemistry, Volume 3, Issue 4, Apr 2006, p. 286 - 288
DOI: https://doi.org/10.2174/157017806776114522
- Available online: 01 Apr 2006

Abstract

A variety of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones were prepared using microwave irradiation as energy source under solvent-free conditions. Reaction times were reduced from 5-14 h to 3-7 min affording high yields from corresponding acyl and aroyl hydrazides.

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2006-04-01

2025-10-04

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Article Type: Research Article

Keyword(s): 4-oxadiazolethiones; 5-substituted-1,3; microwave-assisted synthesis

Synthesis of 5-Substituted-1,3,4-Oxadiazole-2(3H)-Thiones Under Microwave Irradiation

Abstract

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