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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis and Biological Evaluation of a New Benzofuran Analogue of 8- HETE
- Source: Letters in Organic Chemistry, Volume 3, Issue 2, Feb 2006, p. 103 - 106
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- 01 Feb 2006
Abstract
The total synthesis of a 2,3-disubstituted benzofuran, designed as a structural analogue of a bioactive arachidonic acid metabolite, the 8-(S)-HETE, is reported. This heterocyclic derivative has been evaluated as dual agonist of the PPARα and PPARγ nuclear receptors.
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