Green Route to the 2,6-Disubstituted Imidazo[2,1-b]-1,3,4-Thiadiazoles by the Cyclocondensation of α-Bromoacetophenone Derivative and 1,3,4- Thiadiazoles Using Ionic Liquids

An eco-friendly facile synthesis of imidazo[2,1-b]-1,3,4-thiadiazoles is described using ionic liquid, [bmim]PF6 (1-butyl-3-methylimidazolium hexafluorophosphate). The use of recyclable catalyst demonstrates the advantages of significant rate enhancement along with improved yields. The protocol is green and effective for producing the desired target moiety.