Circular Dichroism in a Chiral Amide Possessing an Achiral Binaphthyl Chromophore

Shinzo Hosoi; Jun Serata; Akiyo Sakushima; Fumiyuki Kiuchi; Ichiro Takahashi; Tomihisa Ohta

doi:10.2174/157017806774964404

ISSN: 1570-1786
E-ISSN: 1875-6255

Circular Dichroism in a Chiral Amide Possessing an Achiral Binaphthyl Chromophore
Authors: Shinzo Hosoi¹, Jun Serata², Akiyo Sakushima³, Fumiyuki Kiuchi⁴, Ichiro Takahashi⁵ and Tomihisa Ohta⁶
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¹ School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan. ² School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan. ³ School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan. ⁴ School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan. ⁵ School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan. ⁶ School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan.
Source: Letters in Organic Chemistry, Volume 3, Issue 1, Jan 2006, p. 58 - 61
DOI: https://doi.org/10.2174/157017806774964404
- Available online: 01 Jan 2006

Abstract

Induced circular dichroism (ICD) was observed in binaphthyl amides of chiral primary amines. The CDs changed to split curves centered at 225 nm after N-methylation. The calculated screw senses of the two naphthyl groups accorded with those expected from their exciton chiralities, indicating a possible application for determination of absolute configuration.

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2006-01-01

2025-09-30

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Article Type: Research Article

Keyword(s): amide; binaphthyl; Cotton effect; exciton chirality; Induced circular dichroism; screw sense

Circular Dichroism in a Chiral Amide Possessing an Achiral Binaphthyl Chromophore

Abstract

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