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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A New and Convenient Method of Generating Alkyl Cyanides from Alcohols and Thiols Using 2,4,6-Trichloro[1,3,5]Triazine/n-Bu4NCN
- Source: Letters in Organic Chemistry, Volume 2, Issue 8, Dec 2005, p. 725 - 730
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- 01 Dec 2005
Abstract
Alkyl cyanides are prepared in good to excellent yields (average yield 93% )by treatment of alcohols and thiols with 2,4,6-trichloro[1,3,5]triazine/n-Bu4NCN in refluxing acetonitrile. This method is highly selective for conversion of 1° alcohols in the presence of 2° and 3° ones and thiols.
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