The Chiral N-Monosubstituted 1,2-diphenyl-2-aminoethanols Promoted Enantioselective Diethylzinc Addition to In Situ Formed Imines

W.- W. Yang; L.- F. Cun; Y.- G. Zhi; A.- Q. Mi; Y.- Z. Jiang; L.- Z. Gong

doi:10.2174/157017805774296939

ISSN: 1570-1786
E-ISSN: 1875-6255

The Chiral N-Monosubstituted 1,2-diphenyl-2-aminoethanols Promoted Enantioselective Diethylzinc Addition to In Situ Formed Imines
Authors: W.- W. Yang¹, L.- F. Cun², Y.- G. Zhi³, A.- Q. Mi⁴, Y.- Z. Jiang⁵ and L.- Z. Gong⁶
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¹ Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu, 610041, China and Graduate School of Chinese Academy of Sciences, Beijing, China. ² Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu, 610041, China and Graduate School of Chinese Academy of Sciences, Beijing, China. ³ Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu, 610041, China and Graduate School of Chinese Academy of Sciences, Beijing, China. ⁴ Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu, 610041, China and Graduate School of Chinese Academy of Sciences, Beijing, China. ⁵ Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu, 610041, China and Graduate School of Chinese Academy of Sciences, Beijing, China. ⁶ Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu, 610041, China and Graduate School of Chinese Academy of Sciences, Beijing, China.
Source: Letters in Organic Chemistry, Volume 2, Issue 7, Nov 2005, p. 605 - 607
DOI: https://doi.org/10.2174/157017805774296939
- Available online: 01 Nov 2005

Abstract

The use of easily accessible N-monosubstituted 1,2-diphenyl-2-aminoethanols as ligands to promote the asymmetric addition of diethylzinc to alkyl- and arylimines generated in situ from the precursors provided optically active N-diphenylphosphinylamines with enantioselectivities of up to 96% ee.

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2005-11-01

2025-09-07

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Article Type: Review Article

Keyword(s): amino alcohols; asymmetric catalysis; diethylzinc addition; imines

The Chiral N-Monosubstituted 1,2-diphenyl-2-aminoethanols Promoted Enantioselective Diethylzinc Addition to In Situ Formed Imines

Abstract

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