Organic Synthesis in Solid Media. Alumina Supported Sodium Hydrogen Sulfate as an Effective and Reusable Catalyst for 'One-Pot' Synthesis of Amides from Ketones in Dry Media Under Microwave Irradiation

A great variety of amides were effectively isolated in high yields from the reaction of ketones and hydroxylamine hydrochloride in the presence of alumina supported sodium hydrogen sulfate catalyst in dry media under microwave irradiation in solvent-free conditions. The major products were formed by the migration of the aryl group of the intermediate ketoximes during Beckmann rearrangement. The catalyst can be reused up to six times after simple washing with diethyl ether.