Full text loading...
- ISSN: 1570-1786
- E-ISSN: 1875-6255
-
A Simple and Effective Method for the Thionation of Amides to Thioamides Using Al2O3-Supported P4S10
- Source: Letters in Organic Chemistry, Volume 2, Issue 4, Jun 2005, p. 330 - 333
-
- 01 Jun 2005
Abstract
A simple and effective method for the thionation of amides to thioamides using Al2O3-supported P4S10 was developed and applied to a series of amides including some heterocyclic examples. The reaction was best performed in anhydrous dioxane at reflux temperature. Yields ranging from 62 - 93% are comparable to, or superior to those obtained with Lawesson's reagent. The method uses inexpensive reagents and has the advantage that reagent-derived byproducts may be removed by a simple hydrolytic workup rather than by chromatography, as required for Lawesson's reagent.
© Bentham Science Publishers