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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Baker's Yeast Reduction of PEG-Linked Acetoacetate
- Source: Letters in Organic Chemistry, Volume 2, Issue 1, Feb 2005, p. 89 - 91
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- 01 Feb 2005
Abstract
Bioreduction of PEG-acetoacetate 1 is achieved using dry baker's yeast in toluene with a small amount of added water. After detachment from the polymer under basic conditions, the corresponding (S)-(+)- 3-hydroxybutanoic acid 3 was esterified with Me3SiCl and ethanol and ethyl (S)-(+)-3-hydroxybutanoate 4 was isolated with 97% e.e. and 70% overall yield.
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