A Simple, High Yield Route to cis-4-(N-Alkylamino)-L-Prolines

Reaction of 1 equivalent of N-“-acetyl-cis-4-azido-L-proline with 1 equivalent of an aldehyde and a catalytic amount of Pd-C under an H2 atmosphere cleanly and efficiently yields the corresponding N-“-acetylcis- 4-(N-γ-alkylamino)-L-proline derivative.