A Simple Approach to DC-Cholesterol, its Analogues and Vitamin D-Based Cationic Lipids for Gene Therapy

Armandodoriano Bianco; Francesco Bonadies; Raffaella Napolitano; Giancarlo Ortaggi

doi:10.2174/1570178053399921

ISSN: 1570-1786
E-ISSN: 1875-6255

A Simple Approach to DC-Cholesterol, its Analogues and Vitamin D-Based Cationic Lipids for Gene Therapy
Authors: Armandodoriano Bianco¹, Francesco Bonadies², Raffaella Napolitano³ and Giancarlo Ortaggi⁴
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¹ Dipartimento di Chimica, Universita degli Studi di Roma “La Sapienza” and Istituto di Chimica Biomolecolare del CNR, Piazzale Aldo Moro, 5 00185 Roma, Italy. ² Dipartimento di Chimica, Universita degli Studi di Roma “La Sapienza” and Istituto di Chimica Biomolecolare del CNR, Piazzale Aldo Moro, 5 00185 Roma, Italy. ³ Dipartimento di Chimica, Universita degli Studi di Roma “La Sapienza” and Istituto di Chimica Biomolecolare del CNR, Piazzale Aldo Moro, 5 00185 Roma, Italy. ⁴ Dipartimento di Chimica, Universita degli Studi di Roma “La Sapienza” and Istituto di Chimica Biomolecolare del CNR, Piazzale Aldo Moro, 5 00185 Roma, Italy.
Source: Letters in Organic Chemistry, Volume 2, Issue 1, Feb 2005, p. 79 - 82
DOI: https://doi.org/10.2174/1570178053399921
- Available online: 01 Feb 2005

Abstract

An improved synthesis of DC-Cholesterol, its analogues and Vitamin D-based lipids for the preparation of liposomes in gene therapy, is described. This synthetic strategy affords significative increase in the yields of DC-Cholesterol and its analogs.

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2005-02-01

2025-10-28

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Article Type: Review Article

Keyword(s): cationic lipids; dc-cholesterol; dc-vitamin d-based cationic lipids; gene therapy; modified curtius reaction

A Simple Approach to DC-Cholesterol, its Analogues and Vitamin D-Based Cationic Lipids for Gene Therapy

Abstract

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