Solution and Solid Phase Functionalization of Imidazo[1,2-a]pyridines

S. E. Kazzouli; A. Berthault; S. Berteina-Raboin; A. Mouaddib; G. Guillaumet

doi:10.2174/1570178053203017

ISSN: 1570-1786
E-ISSN: 1875-6255

Solution and Solid Phase Functionalization of Imidazo[1,2-a]pyridines
Authors: S. E. Kazzouli¹, A. Berthault², S. Berteina-Raboin³, A. Mouaddib⁴ and G. Guillaumet⁵
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¹ Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d;Orleans, BP 6759, 45067 Orleans Cedex 2, France. ² Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d;Orleans, BP 6759, 45067 Orleans Cedex 2, France. ³ Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d;Orleans, BP 6759, 45067 Orleans Cedex 2, France. ⁴ Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d;Orleans, BP 6759, 45067 Orleans Cedex 2, France. ⁵ Institut de Chimie Organique et Analytique, UMR CNRS 6005, Universite d;Orleans, BP 6759, 45067 Orleans Cedex 2, France.
Source: Letters in Organic Chemistry, Volume 2, Issue 2, Mar 2005, p. 184 - 187
DOI: https://doi.org/10.2174/1570178053203017
- Available online: 01 Mar 2005

Abstract

The Sonogashira cross-coupling with terminal alkynes and Buchwald coupling with aliphatic alcohols in position 6 of 2-phenylimidazo[1,2-a]pyridines was described. The position 3 was functionalized with various terminal alkynes in solution and on solid support to synthesize 3-substituted imidazo[1,2- a]pyridine derivatives.

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2005-03-01

2025-09-12

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Article Type: Review Article

Keyword(s): 2-bromoacetophenone; alkynes; copper-catalyzed coupling; cross-coupling reaction; Iodination; palladium-coupling catalysis; pyridine

Solution and Solid Phase Functionalization of Imidazo[1,2-a]pyridines

Abstract

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