A Very Short and Efficient Synthesis of Preclamol

Arnault d. Filippis; Domingo Gomez Pardo; Janine Cossy

doi:10.2174/1570178053202883

ISSN: 1570-1786
E-ISSN: 1875-6255

A Very Short and Efficient Synthesis of Preclamol
Authors: Arnault d. Filippis¹, Domingo Gomez Pardo² and Janine Cossy³
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¹ Laboratoire de Chimie Organique associe au CNRS, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), 10 rue Vauquelin, 75231 Paris Cedex 05, France. ² Laboratoire de Chimie Organique associe au CNRS, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), 10 rue Vauquelin, 75231 Paris Cedex 05, France. ³ Laboratoire de Chimie Organique associe au CNRS, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Source: Letters in Organic Chemistry, Volume 2, Issue 2, Mar 2005, p. 136 - 138
DOI: https://doi.org/10.2174/1570178053202883
- Available online: 01 Mar 2005

Abstract

A very short and efficient synthesis of preclamol is described. The key step is the palladiumcatalysed arylation of the zinc enolate of N-propyl-2-piperidinone.

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2005-03-01

2025-09-09

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Article Type: Review Article

Keyword(s): arylations; coupling reaction; lactams; palladium; preclamol; zinc

A Very Short and Efficient Synthesis of Preclamol

Abstract

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